足底测试仪

附加信息

特征	优点
仪器自动记录爪缩回时间	不会因人为因素产生误差
配备USB接口，且配置中包含软件	可单独工作，也可连接电脑使用
动物箱部分可适当调整 (最多可容纳12只小鼠)	根据大、小鼠，优化其活动空间

命令：	软键		数据转移：	配备的闪存
数据读取：	液晶屏显示		电源：	universal mains 85-264 VAC, 50-60Hz
打印：	热敏打印机（需另外购买）		工作温度	15° - 30° C
开始：	红外光源开关		声级：	< 70 dB
红外光强度：	01-99 级间可调		校准：	红外辐射计
反应时间：	显示在液晶屏上；分辨率为0.1s		连接电脑：	DELTA 9-pin 连接器. 参看说明书3.5
红外灯泡：   规格： 动物罩子： 净重： 毛重： 包装规格：	Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W 85 x 40 x 35 cm 3个，每个20x20x14(h)cm 13.0kg 约27.5kg  109 x 53 x 55 cm

 

足底测试仪刺激强度值（红外热辐射值）对照表（单位：mW/cm²）

 

刺激强度	0	10	20	30	40	50	60	70	80	90	99
标准值辐射值	21±1	67±10	103±10	135±7	165±7	190±1	219±7	245±7	270±10	295±10	317±20

The Hargreaves’ Method enables the researcher to discern a peripherally mediated response to thermal stimulation caused by drugs in the unrestrained rat.

Classically the measurement of acute nociceptive thermal threshold in laboratory animals has primarily relied upon the tail flick and hot plate methods. Although both methods are still used frequently in pharmacological studies, they are not without limitation. In addition, neither method has been extended to investigating behavioural responses to hyperalgesia.

The Plantar Test represents a remarkable advance in methodology, as it combines the best features of all other methods of measuring pain sensitivity:

• it allows bilateral testing, like the Randall-Selitto (paw pressure) method
• the behavioral end point is detected automatically, as with the Tail Flick method
• it stimulates the glabrous normal skin of the foot, as opposed to the unique tissue of the tail, as does the Hot Plate method
• repeated testing does not result in sensitization, an advantage shared only with the Tail Flick method
• orofacial stimulation, by optional holders

Unique to the Plantar Test, the animal is unrestrained and unhandled during experiments, which enables other more subjective measures of behaviour to be recorded.

These measures, unavailable with any other method of analgesia testing, provide additional information about the effect of the drug and the state of the animal.

 

37370	足底测试仪 (Hargreaves’ test), 标准套件
37370-001	控制主机
37370-002	探头
37000-003	工作台
37370-327	支架
37000-006	模块式动物围栏 (No. 3 Modules M-S 085)
37370-005	Framed Glass Pane
E-AU 041	存储卡，包含以下
	37370-302      安装说明 52050-10        CUB 数据采集软件包
52010-323	USB 数据线
SPARES
E-HR 002	替换灯泡 (Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W)
M-S 085	替换实验笼
选配
37300	红外热辐射
37370-278	附加实验原件，包括玻璃面板和动物束缚器
37100	大鼠束缚器，用于测试下颌部三叉神经痛
37000-145	面板内嵌式打印机
57145	微型打印机

 

 

 

 

 

 

{module Bibliography on 37370}

• K.M. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris: ”A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hy-peralgesia” Pain 32: 77-88, 1988
• D.C. Yeomans & H.K. Proudfit: ”Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat” Pain 59: 85-97, 1994